What to expect: Guests are welcomed into a large, ornate lobby with high ceiling, crystal chandeliers, marble floor, and numerous sitting areas. On Friday and Saturday evenings, a pianist entertains on composer/conductor André Previn’s grand piano from the Pittsburgh Symphony. Built in 1916 and extensively renovated, the Omni William Penn Hotel caters to business clientele during the week and leisure travelers who come for sports, shopping, museums, and cultural events on weekends.

Insider tip: The Pittsburgh History & Landmarks Foundation offers architecture, art, history, and neighborhood tours for $5 (subject to change). Popular choices include the Bridges & More Downtown Walking Tour, Old Allegheny County Jail Museum Tour, and family-friendly Downtown Dragons Tour. Some tours are held annually, others weekly.

What to expect: Guests in a hurry can bypass the front desk by going directly to the lobby check-in kiosk. The Hyatt caters to business travelers and corporate groups without sacrificing aesthetics. The modern, sleek lobby has a marble floor, natural light, light-oak columns, and brushed stainless-steel elevator doors. The convenient location with direct walkway access to the airport is ideal for travelers with early-morning flights.

Amenity highlights: The Hyatt Regency’s huge health club, complimentary to guests, features a 50-foot indoor lap pool, a sauna, a spa tub, and a fitness room with state-of-the-art cardio and weight equipment. The hotel’s full-service business center is open around the clock and staffed during business hours. Wireless Internet access (surcharge) is available in the lobby, meeting rooms, and guestrooms.

Insider tip: For guests arriving by car, follow signs to “Hotel,” not “Hotel Parking.” Pull up to the front of the hotel, unload and check in, and then move the car to the parking lot. This saves having to transport luggage from the parking lot. Use the car to visit IKEA, five miles away—the only IKEA within 300 miles.